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Home / Proteins & Peptide

Recombinant Human BMP4

SKU : BHP10900228

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z102675
Description	BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They not only promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signalling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP4 and BMP7 are also known to be involved in the differentiation of sympathetic neurons. With
Alternative Names	BMP-2B ; DVR4 ; BMP-4
Quantity	10 µg
Regulatory	RUO
Source	HEK293
Host	Human
Endotoxin Level	<1 EU/µg of recombinant protein as determined by the LAL method
Biological Activity Comment	The EC(50) as determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line) was found to be ≤ 20 ng/mL.

Weight	34 kDa, disulfide linked homodimer, glycosylated

Description	A quick spin of the vial followed by reconstitution in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Format	Lyophilized Powder 2x PBS + 6% Ethanol
Purity	>95% as determined by SDS-PAGE
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months. Avoid repeated freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900228	Z102675	10µg	$390.50		Add to Cart

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