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Home / Proteins & Peptide

Recombinant Human Bifunctional polynucleotide phosphatase/kinase(PNKP)

SKU : BHP10501501

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP857031HU
Alternative Names	DNA 5'-kinase/3'-phosphatasePolynucleotide kinase-3'-phosphatase 2 domains:Polynucleotide 3'-phosphatase (EC:3.1.3.32) ,2'(3')-polynucleotidasePolynucleotide 5'-hydroxyl-kinase (EC:2.7.1.78), DNA 5'-kinase/3'-phosphatasePolynucleotide kinase-3'-phosphatase 2 domains:Polynucleotide 3'-phosphatase (EC:3.1.3.32) ; 2'(3')-polynucleotidasePolynucleotide 5'-hydroxyl-kinase (EC:2.7.1.78)
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either roving 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-521aa
Mol Weight	73.1kDa
Nature	recombinant
Protein Description	Full Length

Involvement In Disease	Microcephaly, seizures, and developmental delay (MCSZ); Ataxia-oculomotor apraxia 4 (AOA4)
Subcellular Location	Nucleus
Uniprot	Q96T60, Q96T60
Database Links	HGNC:9154 OMIM:605610 KEGG:hsa:11284 STRING:9606.ENSP00000323511 UniGene:Hs.78016
Function	Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
Protein Families	DNA 3' phosphatase family
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193).
Weight	73kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501501	CSB-EP857031HU	1mg	$1812		Add to Cart
BHP10501501	CSB-EP857031HU	100ug	$419		Add to Cart
BHP10501501	CSB-EP857031HU	20ug	$224		Add to Cart

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