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Home / Proteins & Peptide

Recombinant Human Beta-amyloid 39/Beta-APP39 Protein (aa 672-710, His & GST Tag)

SKU : BHP10302975

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031464
Alternative Names	AAA;ABETA;ABPP;AD1;APPI;CTFgamma;CVAP;PN-II;PN2
Reconstitution	Please refer to the printed manual for detailed information.
Background	Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons; and is suggested as a regulator of synapse formation and neural plasticity. APP can be processed by two different proteolytic pathways. In one pathway; APP is cleaved by β- and γ-secretase to produce the amyloid-β-protein (Aβ; Abeta; beta-amyloid) which is the principal component of the amyloid plaques; the major pathological hallmark of Alzheimer’s disease (AD); while in the other pathway; α-secretase is involved in the cleavage of APP whose product exerts antiamyloidogenic effect and prevention of the Aβ peptide formation. The aberrant accumulation of aggregated beta-amyloid peptides (Abeta) as plaques is a hallmark of AD neuropathology and reduction of Abeta has become a leading direction of emerging experimental therapies for the disease. Besides this pathological function of Abeta; recently published data reveal that Abeta also has an essential physiological role in lipid homeostasis. Cholesterol increases Abeta production; and conversely A beta production causes a decrease in cholesterol synthesis. Abeta may be part of a mechanism controlling synaptic activity; acting as a positive regulator presynaptically and a negative regulator postsynaptically. The pathological accumulation of oligomeric Abeta assemblies depresses excitatory transmission at the synaptic level; but also triggers aberrant patterns of neuronal circuit activity and epileptiform discharges at the network level. Abeta-induced dysfunction of inhibitory interneurons likely increases synchrony among excitatory principal cells and contributes to the destabilization of neuronal networks. There is evidence that beta-amyloid can impair blood vessel function. Vascular beta-amyloid deposition; also known as cerebral amyloid angiopathy; is associated with vascular dysfunction in animal and human studies. Alzheimer disease is associated with morphological changes in capillary networks; and soluble beta-amyloid produces abnormal vascular responses to physiological and pharmacological stimuli.
Reactivity	Human
Tag	N-His & GST
Description	A DNA sequence encoding the amino acids (Asp672-Val710) of human Amyloid beta A4 protein (APP770) (P05067-1); corresponding to the Beta-amyloid protein 39; was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Formulation	Lyophilized from sterile 50 mM Tris; 100 mM NaCl; 20% glycerol; 0.05% Tween 20; pH 9.5
Host	E.coli
Accession Number	P05067-1
Endotoxin Level	Please contact us for more information.
Mol Weight	32.2 kDa
Mw(kda)	32.2 kDa

Sequence Info	Asp672-Val710

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 85 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302975	PKSH031464	100ug	$855		Add to Cart

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