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Home / Proteins & Peptide

Recombinant Human BCL2/adenovirus E1B 19KDA protein-interacting protein 3-like(BNIP3L)

SKU : BHP10502219

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP002767HU
Alternative Names	Adenovirus E1B19K-binding protein B5, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, NIP3-like protein X, NIP3L, Adenovirus E1B19K-binding protein B5 ; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A ; NIP3-like protein X ; NIP3L
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-likeAlternative name(s): Adenovirus E1B19K-binding protein B5 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A NIP3-like protein X Short name= NIP3L
Expression Region	1-219aa
Mol Weight	25.9kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Nucleus envelope, Endoplasmic reticulum, Mitochondrion outer membrane, Membrane, Single-pass membrane protein
Uniprot	O60238, O60238
Database Links	HGNC:1085 OMIM:605368 KEGG:hsa:665 STRING:9606.ENSP00000370003 UniGene:Hs.131226
Function	Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP
Protein Families	NIP3 family
Research Area	Cancer
Weight	25.93kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502219	CSB-YP002767HU	500ug	$1298		Add to Cart
BHP10502219	CSB-YP002767HU	100ug	$470		Add to Cart
BHP10502219	CSB-YP002767HU	20ug	$250		Add to Cart

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