Recombinant Human Bcl-2-like protein 11(BCL2L11)

Mfr.No.	CSB-EP002615HU
Alternative Names	Bcl2-interacting mediator of cell death
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Bcl-2-like protein 11; Short name= Bcl2-L-11; Alternative name(s): Bcl2-interacting mediator of cell death
Expression Region	1-198aa
Mol Weight	38.2kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Endomembrane system, Peripheral membrane protein, Note=Associated with intracytoplasmic membranes, SUBCELLULAR LOCATION: Isoform BimEL: Mitochondrion
Uniprot	O43521, O43521
Database Links	HGNC:994 OMIM:603827 KEGG:hsa:10018 STRING:9606.ENSP00000376943 UniGene:Hs.469658
Function	Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Pathway	PI3K-Akt signaling pathway; Apoptosis; MAPK Erk pathway; FoxO signaling pathway
Protein Families	Bcl-2 family
Research Area	Cancer
Tissue Specificity	Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis
Weight	38.17kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol