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Recombinant Human Bcl-2-like protein 1(BCL2L1),partial

SKU : BHP10500355

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP002613HU
Alternative Names	Apoptosis regulator Bcl-X
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial mbrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial mbrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles.Isoform Bcl-X(S) promotes apoptosis.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-209aa
Mol Weight	39.4kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Isoform Bcl-X(L): Mitochondrion inner membrane, Mitochondrion outer membrane, Mitochondrion matrix, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Cytoplasm, cytosol, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus membrane, Single-pass membrane protein, Cytoplasmic side
Uniprot	Q07817, Q07817
Database Links	HGNC:992 OMIM:600039 KEGG:hsa:598 STRING:9606.ENSP00000302564 UniGene:Hs.516966
Function	Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION
Pathway	Jak-STAT signaling pathway; PI3K-Akt signaling pathway; NF-kappa B signaling pathway; Apoptosis; Autophagy; Ras signaling pathway; NOD-like receptor signaling pathway
Protein Families	Bcl-2 family
Research Area	Cancer
Tissue Specificity	Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Weight	39.4kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500355	CSB-EP002613HU	1mg	$1812		Add to Cart
BHP10500355	CSB-EP002613HU	100ug	$419		Add to Cart
BHP10500355	CSB-EP002613HU	20ug	$224		Add to Cart

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