Recombinant Human Atrial natriuretic peptide receptor 2(NPR2),partial

Mfr.No.	CSB-EP016024HU
Alternative Names	Atrial natriuretic peptide receptor type B ,ANP-B ,ANPR-B ,NPR-BGuanylate cyclase B ,GC-B, Atrial natriuretic peptide receptor type B ; ANP-B ; ANPR-B ; NPR-BGuanylate cyclase B ; GC-B
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	23-458aa
Mol Weight	64.5kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Acromesomelic dysplasia, Maroteaux type (AMDM); Epiphyseal chondrodysplasia, Miura type (ECDM); Short stature with non-specific skeletal abnormalities (SNSK)
Subcellular Location	Cell membrane, Single-pass type I membrane protein
Uniprot	P20594, P20594
Database Links	HGNC:7944 OMIM:108961 KEGG:hsa:4882 STRING:9606.ENSP00000341083 UniGene:Hs.78518
Function	Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
Pathway	Vascular smooth muscle contraction; cGMP-PKG signaling pathway
Protein Families	Adenylyl cyclase class-4/guanylyl cyclase family
Research Area	Cardiovascular
Weight	64.5kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol