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Recombinant Human ATP-sensitive inward rectifier potassium channel 1(KCNJ1),partial

SKU : BHP10504112

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP012047HU
Description	In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of Extracellular domain potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
Alternative Names	ATP-regulated potassium channel ROM-KInward rectifier K(+) channel Kir1.1,Potassium channel, inwardly rectifying subfamily J member 1, ATP-regulated potassium channel ROM-KInward rectifier K(+) channel Kir1.1 ; Potassium channel, inwardly rectifying subfamily J member 1
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of Extracellular domain potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	178-391
Mol Weight	28.3kDa
Nature	Recombinant
Protein Description	Partial

Involvement In Disease	Bartter syndrome 2, antenatal (BARTS2)
Subcellular Location	Cell membrane, Multi-pass membrane protein
Uniprot	P48048, P48048
Database Links	HGNC:6255 OMIM:241200 KEGG:hsa:3758 STRING:9606.ENSP00000376432 UniGene:Hs.527830
Function	In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
Protein Families	Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ1 subfamily
Research Area	Signal Transduction
Tissue Specificity	In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.
Weight	28.3 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10504112	CSB-EP012047HU	1mg	$1812		Add to Cart
BHP10504112	CSB-EP012047HU	100ug	$419		Add to Cart
BHP10504112	CSB-EP012047HU	20ug	$224		Add to Cart

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