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Home / Proteins & Peptide

Recombinant Human Angiopoietin-2/ANG2 (C-6His)

SKU : BHP10304853

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH033915
Description	Recombinant Human Angiopoietin-2 is produced by our Mammalian expression system and the target gene encoding Lys275-Phe496 is expressed with a 6His tag at the C-terminus.
Alternative Names	AGPT2; ANG2; ANG-2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B;angiopoitin 2; ANGPT2; Tie2-ligand
Reconstitution	Please refer to the printed manual for detailed information.
Background	Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Tie-2. While Ang-1 is a potent Tie 2 agonist, Ang-2 may act as either a Tie-2 antagonist or agonist, depending upon its state of multimerization. The higher the order of oligomer, the more effective Ang-2 becomes as a Tie-2 agonist. The short isoform appears to block the binding of either Ang-1 or full-length Ang-2 to Tie-2. Ang-2 functions as a pro-angiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. In addition, ANG-2 is strongly expressed in the vasculature of many tumors and it has been suggested that ANG-2 may act synergistically with other cytokines such as vascular endothelial growth factor to promote tumor-associated Angiogenesis and tumor progression.
Reactivity	Human
Tag	C-6His
Formulation	Lyophilized from a 0.2 um filtered solution of 20 mM MOPS, 150 mM NaCl, 0.1% CHAPS, pH 7.5.
Host	Human Cells
Accession Number	O15123
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	23.6 kDa
Mw(kda)	23.6 kDa

Sequence Info	Lys275-Phe496

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	>95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10304853	PKSH033915	10ug	$139		Add to Cart
BHP10304853	PKSH033915	50ug	$416		Add to Cart

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