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Recombinant Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 protein(AIMP1) (Active)

SKU : BHP10500285

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-AP002281HU
Alternative Names	Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide II, EMAP-II, Small i, Multisynthase complex auxiliary component p43 ; Endothelial monocyte-activating polypeptide II ; EMAP-II ; Small i
Antigen	AIMP1
Pubmed Id	7929199; 14702039; 15489334; 10358004; 10850427; 11306575; 12237313; 11818442; 14500886; 16472771; 17443684; 19362550; 21092922; 20068231; 21269460; 22223895; 22814378; 24275569; 10852899; 11157763
Regulatory	RUO
Source	E.coli
Endotoxin Level	Less than 1.0 EU/μg as determined by LAL method.
Bioactivity	Fully biologically active when compared to standard. The ED50 as determined by the apoptotic effect using serum free human MCF-7 cells is less than 40 ng/ml, corresponding to a specific activity of >2.5x10⁴ IU/mg.
Expression Region	147-312aa
Mol Weight	18.2 kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Leukodystrophy, hypomyelinating, 3 (HLD3)
Subcellular Location	Nucleus, Cytoplasm, cytosol, Cytoplasmic vesicle, secretory vesicle, Secreted, Endoplasmic reticulum, Golgi apparatus
Uniprot	Q12904, Q12904
Database Links	HGNC:10648 OMIM:260600 KEGG:hsa:9255 STRING:9606.ENSP00000378191 UniGene:Hs.591680
Function	Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
Research Area	Cancer
Weight	18.2 kDa

Buffer	0.2 µm filtered PBS, pH 7.4,lyophilized
Purity	>98% as determined by SDS-PAGE and HPLC.
Storage Buffer	0.2 μm filtered PBS, pH 7.4 ,lyophilized

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500285	CSB-AP002281HU	500ug	$3438		Add to Cart
BHP10500285	CSB-AP002281HU	100ug	$1534		Add to Cart
BHP10500285	CSB-AP002281HU	5ug	$142		Add to Cart

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