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Home / Proteins & Peptide

Recombinant Human ALK1 (N-GST tag)

SKU : BHP10900843

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500009
Description	ALK1 is a serine/threonine-protein kinase receptor R3 precursor that mediates signal by TGFß superfamily . ALK1 functions as a TGFß type I receptor in endothelial cells and is responsible for human hereditary hemorrhagic telangiectasia (HHT) type II. Distinct Smad proteins (i.e., Smad2/Smad3 and Smad1/Smad5) show interaction with ALK1 and mediate TGFß signaling. Northern blot and RT-PCR analysis show that ALK1 specifically induces expression of Smad6, Smad7, Id1, Id2, endoglin, STAT1, and interleukin 1 receptor in endothelial cells. ALK1 expression in inflammatory myofibroblastic tumor of the urinary bladder have also has been reported .
Alternative Names	ACVRL1 ; ACVRLK1 ; ALK1 ; HHT ; HHT2 ; ORW2 ; SKR3 ; TSR-I
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of ALK1 was determined to be 22 nmol /min/mg as per activity assay protocol.

Weight	64.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900843	Z500009	10µg	$361.11		Add to Cart

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