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Home / Proteins & Peptide

Recombinant Human ALCAM/CD166 Protein (His Tag)(Active)

SKU : BHP10303086

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031919
Description	A DNA sequence encoding the extracellular domain (Met 1-Ala 526) of human ALCAM (NP_001618.2) was expressed, with the C-terminal polyhistidine tag.
Alternative Names	CD166 antigen; Activated leukocyte cell adhesion molecule; CD166; ALCAM; MEMD
Reconstitution	Please refer to the printed manual for detailed information.
Background	Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. The extracellular domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains), of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Recently, homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression. And CD166 is regarded as a potential novel breast cancer indicator and therapeutic target.
Reactivity	Human
Tag	C-His
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_001618.2
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	Immobilized human ALCAM-His at 10 ug/ml (100 ul/well) can bind mouse CD6-Fc , The EC50 of mouse CD6-Fc is 0.1-0.22 ug/ml.
Mol Weight	57.4 kDa
Mw(kda)	57.4 kDa

Sequence Info	Met 1-Ala 526

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 98 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303086	PKSH031919	100ug	$486		Add to Cart

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