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Home / Proteins & Peptide

Recombinant Human 7,8-dihydro-8-oxoguanine triphosphatase(NUDT1)

SKU : BHP10505318

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP016154HUa0
Description	Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
Alternative Names	2-hydroxy-dATP diphosphatase (EC:3.6.1.56) 8-oxo-dGTPase Nucleoside diphosphate-linked moiety X motif 1 MTH1
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	2-hydroxy-dATP diphosphatase (EC:3.6.1.56); 8-oxo-dGTPase; Nucleoside diphosphate-linked moiety X motif 1; MTH1
Expression Region	19-197aa
Mol Weight	22.3 kDa
Nature	Recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Isoform p18: Cytoplasm, Mitochondrion matrix, Nucleus
Uniprot	P36639, P36639
Database Links	HGNC:8048 OMIM:600312 KEGG:hsa:4521 STRING:9606.ENSP00000339503 UniGene:Hs.534331
Function	Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A
Protein Families	Nudix hydrolase family
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
Weight	22.3 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 85% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer，50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10505318	CSB-YP016154HUa0	500ug	$1593		Add to Cart
BHP10505318	CSB-YP016154HUa0	100ug	$576		Add to Cart
BHP10505318	CSB-YP016154HUa0	20ug	$306		Add to Cart

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