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Home / Proteins & Peptide

Recombinant Human 14-3-3 sigma/YWHAS Protein (GST Tag)

SKU : BHP10302952

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031401
Description	A DNA sequence encoding the human SFN (NP_006133.1) (Met 1-Ser 248) was fused with the GST tag at the N-terminus.
Alternative Names	14-3-3 Protein Sigma; Epithelial Cell Marker Protein 1; Stratifin; SFN; HME1
Reconstitution	Please refer to the printed manual for detailed information.
Background	14-3-3 protein sigma (YWHAS); also known as stratifin (SFN) and epithelial cell marker protein 1; is a member of the14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases; phosphatases; and transmembrane receptors; and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2; and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally; YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.
Reactivity	Human
Tag	N-GST
Formulation	Lyophilized from sterile 20mM Tris; 150mM NaCl; 10mM GSH; 25% glycerol; pH 8.0
Host	E.coli
Accession Number	NP_006133.1
Endotoxin Level	Please contact us for more information.
Mol Weight	50.1 kDa
Mw(kda)	50.1 kDa

Sequence Info	Met 1-Ser 248

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 94 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302952	PKSH031401	100ug	$805		Add to Cart

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