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Home / Proteins & Peptide

Recombinant Human 14-3-3 beta/YWHAB Protein (GST Tag)

SKU : BHP10302950

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031394
Description	A DNA sequence encoding the human YWHAB (NP_003395.1) (Met 1-Asn 246) was fused with the GST tag at the N-terminus.
Alternative Names	GW128;HEL-S-1;HS1;KCIP-1;YWHAA
Reconstitution	Please refer to the printed manual for detailed information.
Background	14-3-3 beta / YWHAB is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 beta / YWHAB is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. 14-3-3 beta / YWHAB interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. 14-3-3 beta / YWHAB has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 beta / YWHAB binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation.
Reactivity	Human
Tag	N-GST
Formulation	Lyophilized from sterile 20mM Tris, 150mM NaCl, 0.1mM DTT, 10% glycerol, pH 7.5
Host	E.coli
Accession Number	NP_003395.1
Endotoxin Level	Please contact us for more information.
Mol Weight	54.9 kDa
Mw(kda)	54.9 kDa

Sequence Info	Met 1-Asn 246

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 96 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302950	PKSH031394	100ug	$732		Add to Cart

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