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Home / Proteins & Peptide

Recombinant Human 11-beta-hydroxysteroid dehydrogenase 1(HSD11B1),partial

SKU : BHP10500619

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP010763HU
Alternative Names	11-beta-hydroxysteroid dehydrogenase 1 ,11-DH ,11-beta-HSD1Short chain dehydrogenase/reductase family 26C member 1, 11-beta-hydroxysteroid dehydrogenase 1 ; 11-DH ; 11-beta-HSD1Short chain dehydrogenase/reductase family 26C member 1
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol .
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	25-292aa
Mol Weight	45.5kDa
Nature	recombinant
Protein Description	partial

Involvement In Disease	Cortisone reductase deficiency 2 (CORTRD2)
Subcellular Location	Endoplasmic reticulum membrane, Single-pass type II membrane protein
Uniprot	P28845, P28845
Database Links	HGNC:5208 OMIM:600713 KEGG:hsa:3290 STRING:9606.ENSP00000261465 UniGene:Hs.195040
Function	Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
Protein Families	Short-chain dehydrogenases/reductases (SDR) family
Tissue Specificity	Widely expressed. Highest expression in liver.
Weight	45.5kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500619	CSB-EP010763HU	1mg	$1812		Add to Cart
BHP10500619	CSB-EP010763HU	100ug	$419		Add to Cart
BHP10500619	CSB-EP010763HU	20ug	$224		Add to Cart

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