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Home / Proteins & Peptide

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1(PLCZ1)

SKU : BHP10501385

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP768240HU
Alternative Names	Phosphoinositide phospholipase C-zeta-1,Phospholipase C-zeta-11, Phosphoinositide phospholipase C-zeta-1 ; Phospholipase C-zeta-11
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating bryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete mbrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-415aa
Mol Weight	64.5kDa
Nature	recombinant
Protein Description	Full length of isoform 2

Involvement In Disease	Spermatogenic failure 17 (SPGF17)
Subcellular Location	Nucleus, Cytoplasm, perinuclear region
Uniprot	Q86YW0, Q86YW0
Database Links	HGNC:19218 OMIM:608075 KEGG:hsa:89869 STRING:9606.ENSP00000266505 UniGene:Hs.743832
Function	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Pathway	Calcium signaling pathway; Phosphatidylinositol signaling system
Tissue Specificity	Expressed specifically in testis and sperm. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic-duct cells from patients with cystic fibrosis.
Weight	63.7kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501385	CSB-EP768240HU	1mg	$1812		Add to Cart
BHP10501385	CSB-EP768240HU	100ug	$419		Add to Cart
BHP10501385	CSB-EP768240HU	20ug	$224		Add to Cart

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