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Home / Proteins & Peptide

Recombinant Dendroaspis angusticeps Fasciculin-2(Fas-2)

SKU : BHP10503401

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP314272DBG
Alternative Names	Short name:Fas-2, Short name:Fas2, Alternative name(s):, Acetylcholinesterase toxin F-VII, Fasciculin-II, Short name:FAS-II, Toxin TA1, Acetylcholinesterase toxin F-VII ; Fasciculin-II ; Short name:FAS-II ; Toxin TA1
Antigen	N/A
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Interferes with neuromuscular transmission by inhibiting the enzyme acetylcholinesterase (AChE) present at the neuromuscular junction. It selectively binds and inhibits with a 1:1 stoichiometry the mammalian and electric fish AChE at picomolar concentrations. It is highly specific for the peripheral site of AChE and blocks the entry of acetylcholine into the active site of the enzyme (through the Met-33 residue), thereby preventing its breakdown. It has been called fasciculin since after injection into mice it causes severe, generalized and long-lasting (5-7 hours) fasciculations.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Fasciculin-2; Short name= Fas-2; Short name= Fas2; Alternative name(s): Acetylcholinesterase toxin F-VII; Fasciculin-II; Short name= FAS-II; Toxin TA1
Expression Region	1-61aa
Mol Weight	22.8kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Secreted
Uniprot	P0C1Z0, P0C1Z0
Function	Interferes with neuromuscular transmission by inhibiting the enzyme acetylcholinesterase (AChE) present at the neuromuscular junction. It selectively binds and inhibits with a 1
Protein Families	Snake three-finger toxin family, Short-chain subfamily, Acn-esterase inhibitor sub-subfamily
Research Area	Others
Tissue Specificity	Expressed by the venom gland.
Weight	22.71kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503401	CSB-EP314272DBG	1mg	$2466		Add to Cart
BHP10503401	CSB-EP314272DBG	100ug	$729		Add to Cart
BHP10503401	CSB-EP314272DBG	20ug	$388		Add to Cart

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