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Home / Proteins & Peptide

Recombinant Cynomolgus PD-1/CD279/PDCD1 Protein (His Tag)

SKU : BHP10306141

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSQ050025
Description	Recombinant Cynomolgus PD-1 is produced by our Mammalian expression system and the target gene encoding Pro21-Gln167 is expressed with a 6His tag at the C-terminus.
Alternative Names	Programmed cell death 1; PD-1; PD1
Reconstitution	Please refer to the printed manual for detailed information.
Background	Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
Reactivity	Cynomolgus
Tag	C-His
Formulation	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Host	Human Cells
Accession Number	B0LAJ3
Endotoxin Level	< 1.0 EU per ?g as determined by the LAL method.
Mol Weight	17.3 kDa
Mw(kda)	17.3 kDa

Sequence Info	Pro21-Gln167

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10306141	PKSQ050025	10ug	$117		Add to Cart
BHP10306141	PKSQ050025	50ug	$297		Add to Cart

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