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Home / Proteins & Peptide

Recombinant Bovine Interferon tau-1(IFNT1)

SKU : BHP10502569

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP322795BO
Alternative Names	Antiluteolysin, Trophoblast antiluteolytic protein, Trophoblast protein 1, TP-1, Trophoblastin, Antiluteolysin ; Trophoblast antiluteolytic protein ; Trophoblast protein 1 ; TP-1 ; Trophoblastin
Antigen	IFNT1
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Interferon tau-1; Short name= IFN-tau-1; Alternative name(s): Antiluteolysin; Trophoblast antiluteolytic protein; Trophoblast protein 1; Short name= TP-1; Trophoblastin
Expression Region	24-195aa
Mol Weight	21.8kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Secreted
Uniprot	P15696, P15696
Database Links	KEGG:bta:317698 STRING:9913.ENSBTAP00000047689 UniGene:Bt.328
Function	Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
Protein Families	Alpha/beta interferon family, IFN-alphaII subfamily
Research Area	Others
Tissue Specificity	Constitutively and exclusively expressed in the mononuclear cells of the extraembryonic trophectoderm.
Weight	21.7kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Bos Taurus (Cattle)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502569	CSB-YP322795BO	500ug	$1916		Add to Cart
BHP10502569	CSB-YP322795BO	100ug	$826		Add to Cart
BHP10502569	CSB-YP322795BO	20ug	$436		Add to Cart

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