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Home / Proteins & Peptide

Recombinant Bovine Interferon-inducible double stranded RNA-dependent protein kinase activator A(PRKRA)

SKU : BHP10505589

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP644142BO
Description	Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner
Alternative Names	Protein activator of the interferon-induced protein kinase Protein kinase, interferon-inducible double-stranded RNA-dependent activator
Tag	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Regulatory	RUO
Relevance	Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner
Source	E.coli
Abbreviation	PRKRA
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double-stranded RNA-dependent activator
Expression Region	1-313aa
Mol Weight	39.4 kDa
Nature	Recombinant
Protein Description	Full Length

Subcellular Location	Cytoplasm, perinuclear region, Cytoplasm
Uniprot	Q2HJ92, Q2HJ92
Database Links	KEGG:bta:282875 STRING:9913.ENSBTAP00000001451 UniGene:Bt.13570
Function	Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).
Protein Families	PRKRA family
Research Area	Epigenetics and Nuclear Signaling
Weight	39.4 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 85% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Bos Taurus (Cattle)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10505589	CSB-EP644142BO	1mg	$2466		Add to Cart
BHP10505589	CSB-EP644142BO	100ug	$729		Add to Cart
BHP10505589	CSB-EP644142BO	20ug	$388		Add to Cart

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