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Recombinant BMP-2, Human

SKU : BHP11300009

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Mfr.No.	BK0010‐100µg
Description	Human Bone Morphogenetic Protein-2 (BMP-2) is a bone-growth regulatory factor and belongs to the transforming growth factor-beta (TGF-beta) superfamily. Human Bone Morphogenetic Protein-2 (BMP-2) is synthesized as large precursor molecule (Met1-Arg396, with a signal peptide from Met1 to Gly23), propeptide (Leu24-Arg282) of which is cleaved by PCSK5 (Proprotein Convertase Subtilisin/Kexin type 5). The active form consists of a dimer of two identical proteins which are linked by a disulfide bond at Cys360. It plays an important role in the development of bone and cartilage, cardiac cell differentiation and epithelial to mesenchymal transition. It is also involved in the hedgehog pathway, TGF-beta signaling pathway, and in cytokine-cytokine receptor interaction. Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) produced in E.coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 115 amino acids. A fully biologically active molecule, rhBMP-2 has a molecular mass of 26 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.
Alternative Names	BMP-2 ; BMP2A ; Bone morphogenetic protein 2 ; BMP-2A ; BMP2
Regulatory	RUO
Source	Escherichia coli.
Host	Human
Endotoxin Level	< 1 EU/μg, determined by LAL method.
Biological Activity Comment	Assay #1: Measured by its ability to induce alkaline phosphatase production by ATDC-5 Cells, The ED50 for this effect is typically 0.07-0.2 µg/mL. Assay #2: Measured by its ability to induce alkaline phosphatase production by C2C12 cells, The ED50 for this effect is typically 0.2-1 µg/mL.
Nature	Recombinant

Weight	26 kDa, observed by non-reducing SDS-PAGE

Description	Reconstituted in 20 mM AcOH or 5 mM HCl. The solubility should be at 100 μg/ml.
Format	Lyophilized after extensive dialysis against 50 mM acetic acid. Sterile Filtered White lyophilized (freeze-dried) powder.
Purity	> 95% as analyzed by non-reducing SDS-PAGE.
Storage	Lyophilized recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhBMP-2 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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SKU	Supplier No.	Size	Your price	Quantity
BHP11300009	BK0010‐100µg	100µg	$730		Add to Cart
BHP11300009	BK0010‐100µg	10μg	$188.67		Add to Cart
BHP11300009	BK0010‐100µg	1mg	$4011.11		Add to Cart
BHP11300009	BK0010‐100µg	50µg	$485.20		Add to Cart

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