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Recombinant Aggregatibacter actinomycetemcomitans Leukotoxin(ltxA),partial

SKU : BHP10505570

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP322853AYK
Description	Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media.
Alternative Names	AaLta lktA
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	AaLta; lktA
Expression Region	721-1055aa
Mol Weight	38.3 kDa
Nature	Recombinant
Protein Description	Partial

Subcellular Location	Cell outer membrane, Peripheral membrane protein, Extracellular side, Secreted
Uniprot	P16462, P16462
Function	Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media.
Protein Families	RTX prokaryotic toxin (TC 1.C.11) family
Research Area	Others
Weight	38.3 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 85% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

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SKU	Supplier No.	Size	Your price	Quantity
BHP10505570	CSB-YP322853AYK	1mg	$2959		Add to Cart
BHP10505570	CSB-YP322853AYK	100ug	$826		Add to Cart
BHP10505570	CSB-YP322853AYK	20ug	$436		Add to Cart

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