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Home / Proteins & Peptide

Recombinant 2019-nCoV S-trimer Protein (C-6His)

SKU : BHP15200040

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ELK Biotechnology

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Mfr.No.	EPT040
Description	Recombinant SARS-CoV-2 S-trimer Protein is produced by our Mammalian expression system and the target gene encoding Cys15-Gln1208 is expressed with a 6His tag at the C-terminus.
Alternative Names	2019-nCov S protein; 2019-nCoV Spike glycoprotein; 2019-nCoV S glycoprotein
Background	The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Biological Activity	Anti-2019-nCoV S-hIgG1 Antibody (8A5)(Cat#DA034) can block Human ACE-2-Avi-His (Cat#CY51) and 2019-nCoV S-trimer Protein-His(Cat#DRA49) interaction, the IC50 for this effect is 25 ng/ml.
Molecular Weight	136.6kDa
Accession Number	QHD43416.1

Shipping	The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.
Purity	Greater than 95%
Storage	Reconstituted protein solution should be stored at <= -20°C.

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SKU	Supplier No.	Size	Your price	Quantity
BHP15200040	EPT040	50ug	$579		Add to Cart

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