Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. N protein packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
Tag
N-6His
Formulation
Supplied as a 0.2 uM filtered solution of 20 mM HEPES, 100 mM NaCl, pH 8.0.
Species
SARS-CoV-2
Host
E.coli
Accession Number
QHD43423.2
Endotoxin Level
< 1.0 EU per ug as determined by the LAL method.
Accurate Molecular Mass(kd)
49.4 kDa
Predicted Molecular Mass(kd)
50-60 kDa
Protein Description
Recombinant 2019-nCoV Nucleocapsid Protein is produced by our E.coli expression system and the target gene encoding Met1-Ala419 is expressed with a 6His tag at the N-terminus.