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Home / Proteins & Peptide

RbBP5, His-tag

SKU : BHP18200635

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Mfr.No.	71202
Description	Human retinoblastoma binding protein 5 (RbBP5), GenBank Accession No. NM_005057, a.a. 2 - 538 (end) with N-terminal His-tag, MW= 60 kDa, expressed in an E. coli expression system.
Background	RbBP5 binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. In embryonic stem (ES) cells, RbBP5 plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3Lys4 methylation at key developmental loci, including that mediated by retinoic acid. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at Lys4 of histone H3.
Immunogen Region	2-538 (end)
Tag	N-terminal His-tag
Formulation	20 mM Tris-HCl, pH 7.4, 300 mM NaCl, 10% glycerol, 1 mM TCEP, and 1 uM ZnCl₂
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Avoid freeze/thaw cycles.
GenBank	NM_005057
Mw(kda)	60 kDa

Synonyms	Rbbp5, retinoblastoma binding protein 5, Set1c WD40 Repeat Protein, SWD1, RBQ3
Uniprot	Q15291

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Cao, F., et al., PLoS One. 2012 Nov 23; 5(11): e14102. 2. Odho, Z., et al., J Biol Chem. 2010 Oct 22; 285(43): 32967-76.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200635	71202	50 ug	$495		Add to Cart

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