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Home / Proteins & Peptide

RbAp48, His-tag

SKU : BHP18200387

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BPS Bioscience

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Mfr.No.	50297
Description	Human RbAp48 (GenBank Accession No. NM_005610), a.a. 2-end with N-terminal His-tag, MW= 48 kDa, expressed in a baculovirus expression system. Host cell line: Sf9 cells
Background	RbAp48 is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; the NURF (nucleosome remodeling factor) complex; and the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes.
Immunogen Region	2-end
Tag	N-terminal His-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 200 mM imidazole
Species	Human
Application	Useful for binding studies to investigate protein-protein interactions in the EZH2 complex. Also suitable as an immunogen or as a standard for Western blotting.
Notes	Avoid freeze/thaw cycles.
GenBank	NM_005610
Mw(kda)	48 kDa

Synonyms	RBAP48, Retinoblastoma Binding Protein 4, NURF55, Chromatin Assembly Factor 1 Subunit C, CAF1 p48, RBBP-4, Retinoblastoma-Binding Protein P48
Uniprot	Q09028

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Varambally, S. et al. Science 322 (5908), 1695-1699 (2008). 2. Rakotobe, D. et al., Virol. J. 5, 32 (2008).

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200387	50297	50 ug	$495		Add to Cart

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