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Home / Proteins & Peptide

PTPu (PTPRM), GST-tag

SKU : BHP18200044

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Mfr.No.	30053
Description	PTPu (mu) (protein tyrosinephosphatase mu, also known as RPTPu),catalytic domain, (a.a. 896-1175), (GenBankAccession No. NM_001105244) withN-terminal GST tag, MW=56.2 kDa,expressed in an E. coli expression system. Specific activity: 60 U/ug
Background	PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion. PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity.
Immunogen Region	896-1175
Tag	N-terminal GST-tag
Formulation	25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione
Species	Human
Application	Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Notes	20 mM HEPES, pH 7.2, 100 mM NaCl, 2 mM EDTA, 1 mM DTT, 1 mM pNPP and 2 ng/ul PTP-mu. Assay was done at room temperature for 5 minutes, and the reaction was monitored at 405 nm continuously. Specific activity was calculated based on epsilon_pNPP= 18,000 M^-1cm^-1. Avoid freeze/thaw cycles.
GenBank	NM_001105244
Mw(kda)	56.2 kDa

Uniprot	P28827

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	>12 months at -80°C

Reference	1. S. Brady-Kalnay, et al., J. Cell Biol 1995, 130: 977. 2. T. Mourton, et al., J. Biol. Chem. 2002, 276:14896.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200044	30053	50 ug was 20 ug	$357.50		Add to Cart

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