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Home / Proteins & Peptide

PTPbeta, GST-tag

SKU : BHP18200038

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BPS Bioscience

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Mfr.No.	30042
Description	Protein tyrosine phosphatase PTPbeta (beta), also known as PTPRB (GenBank accession No. X54131), a.a. 1675-1996 (catalytic domain) with N-terminal GST-tag, MW=63.7 kDa, expressed in an E. coli expression system. Specific activity: 57 nmole/min/ug Unit definition: One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C.
Background	Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells.
Immunogen Region	1675-1996
Tag	N-terminal GST-tag
Formulation	25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione
Species	Human
Application	Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Notes	20 mM HEPES, pH 7.2, 100 mM NaCl, 2 mM EDTA, 1 mM DTT, 1 mM pNPP and PTPbeta. Assay was done at 30°C for 5 minutes, and the reaction was monitored at 405 nm continuously. Specific activity was calculated based on epsilon_pNPP= 18,000 M^-1cm^-1. Avoid freeze/thaw cycles.
GenBank	X54131
Mw(kda)	63.7 kDa

Synonyms	PTPB, PTPRB, VEPTP, PTPbeta, RPTbeta, PTPbeta
Uniprot	P23467

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	>12 months at -80°C

Reference	1. I. K. Lund et al., J Biol Chem. 2004, 279: 24226-35. 2. G.H. Peters et al., Biochimie. 2003, 85: 527-34.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200038	30042	50 ug was 20 ug	$357.50		Add to Cart

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