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Home / Proteins & Peptide

PTP1B (PTPN1) full length, GST-tag

SKU : BHP18200026

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Mfr.No.	30009
Description	Protein tyrosine phosphatase PTP1B, also known as PTPN1 (GenBank accession number M31724), full length, (a.a. 1-436), with N terminal GST-tag, MW=76 kDa, expressed in an E. coli expression system. Specific activity: 2,000 pmole/min/ug Unit definition: One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C.
Background	Protein tyrosine phosphatase nonreceptor, type 1 (PTPN1) is the founding member of the protein tyrosine phosphatase (PTP) family. PTPN1 catalyze the hydrolysis of the phosphate monoesters specifically from tyrosine residues. PTPN1 is known to be involved in signaling pathways that regulate a variety of cellular processes including cell growth and oncogenic transformation. PTPN1 also has been shown to act as a negative regulator of insulin signaling. PTPN1 has also been reported to dephosphorylate epidermal growth factor receptor kinase, which implicated the role of this phosphatase in cell growth control and cell response to interferon stimulation.
Immunogen Region	1-436
Tag	N-terminal GST-tag
Formulation	45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 10% glycerol, 18 mM glutathione, and 3 mM DTT.
Species	Human
Application	Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Notes	50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP. Avoid freeze/thaw cycles.
GenBank	M31724
Mw(kda)	76 kDa

Synonyms	PTP1B, PTPN1, Protein tyrosine phosphatase 1B
Uniprot	P18031

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Frangioni et al., Cell, 1992, 68: 545. 2. M. Elchebly et al., Science 1999, 283: 1544.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200026	30009	50 ug was 20 ug	$357.50		Add to Cart

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