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Home / Proteins & Peptide

PTP1B(1-321)/PTPN1, GST-tag

SKU : BHP18200027

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Mfr.No.	30010
Description	Human PTP1B protein tyrosine phosphatase, also known as PTPN1 (GenBank accession no. M31724), a.a. 1-321 (catalytic domain), with N-terminal GST-tag, MW=63.3 kDa, expressed in E. coli. Specific activity: 780 pmole/min/ug
Background	Protein tyrosine phosphatase nonreceptor, type 1 (PTPN1) is the founding member of the protein tyrosine phosphatase (PTP) family. PTPN1 catalyze the hydrolysis of the phosphate monoesters specifically from tyrosine residues. PTPN1 is known to be involved in signaling pathways that regulate a variety of cellular processes including cell growth and oncogenic transformation. PTPN1 also has been shown to act as a negative regulator of insulin signaling. PTPN1 has also been reported to dephosphorylate epidermal growth factor receptor kinase, which implicated the role of this phosphatase in cell growth control and cell response to interferon stimulation.
Immunogen Region	1-321
Tag	N-terminal GST-tag
Formulation	25 mM Tris-HCl, 75 mM NaCl, pH 8.0, 0.05% Tween-20, 10 mM glutathione, 1 mM DTT and 50% glycerol
Species	Human
Application	Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Notes	20 mM HEPES, pH 7.2, 100 mM NaCl, 2 mM EDTA, 1 mM DTT, 1 mM pNPP and PTPase. Assay was done at RT for 15 min, and the reaction was monitored at 405 nm continuously. Specific activity was calculated based on epsilon_pNPP= 18,000 M^-1cm^-1. Avoid freeze/thaw cycles.
GenBank	M31724
Mw(kda)	63.3 kDa

Synonyms	PTP1B, PTPN1, Protein tyrosine phosphatase 1B
Uniprot	P18031

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	>12 months at -80°C

Reference	1. Frangioni et al., Cell, 1992, 68: 545. 2. M. Elchebly et al., Science 1999, 283: 1544.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200027	30010	50 ug was 20 ug	$357.50		Add to Cart

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