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Home / Proteins & Peptide

PRL3 (2-173), His-tag

SKU : BHP18200025

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Mfr.No.	30002
Description	Human PRL 3 (GenBank Accession No. NM_032611), a.a. 2-173 with N-terminal His-tag, MW = 19.5 kDa, expressed in an E. coli expression system. Specific activity: 0.53 pmol/min/ug
Background	Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Immunogen Region	2-173
Tag	N-terminal His-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2mM KCl, 20% glycerol, and 3 mM DTT.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Assay conditions: enzyme was incubated in 50 mM Tris pH 7.4, 150 mM NaCl, 5 mM DTT, and 12.5 mM PNPP as a substrate for 2 hours at 37°C. Absorbance was read by Tecan spectraphotometer at 405 nm wavelength. Avoid freeze/thaw cycles.
GenBank	NM_032611
Mw(kda)	19.5 kDa

Synonyms	PRL-3, PTP4A3, PTPIVa, PTPCAAX3, Phosphatase Of Regenerating Liver 3
Uniprot	O75365

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	>12 months at -80°C

Reference	1. Dai N. et al., World J. Gastroenterol. 15 (12), 1499-1505 (2009). 2. Radke I. et al., Br. J. Cancer 95 (3), 347-354 (2006).

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200025	30002	50 ug	$357.50		Add to Cart

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