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Home / Proteins & Peptide

PLK1 Polo Box Domain, GST-tag

SKU : BHP18200389

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BPS Bioscience

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Mfr.No.	50301
Description	Human Plk1 polo box domain (GenBank Accession No. NM_005030), a.a. 367-end with N-terminal GST-tag, MW=53 kDa, expressed in an E. coli expression system.
Background	PLK1 is a member of the Polo-Like Kinase family that localize to centrosomes or spindle pole bodies and undergo dramatic subcellular relocation during the cell cycle. Deregulated activities of PLKs often result in abnormalities in centrosome duplication, maturation, and/or microtubule dynamics. PLKs also regulate the function of the Golgi complex. Deregulated expression of human PLK1 is strongly correlated with the development of many types of malignancies, and ectopic expression of PLK1 dominant negative protein leads to rapid cell death.
Immunogen Region	367-end
Tag	N-terminal GST-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 16 mM glutathione
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Avoid freeze/thaw cycles.
GenBank	NM_005030
Mw(kda)	53 kDa

Synonyms	STPK13, polo-like kinase 1
Uniprot	P53350

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	Garcia lvarez et al., Acta Cryst. (2006). F62, 372-375.

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200389	50301	100 ug	$456.50		Add to Cart

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