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Home / Proteins & Peptide

PHIP (BD1), His-tag

SKU : BHP18200113

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Mfr.No.	31140
Description	Human bromodomain pleckstrin homology domain interacting protein (PHIP), also known as IRS-1 PH Domain-Binding Protein, WDR11, and BRWD2, GenBank Accession No. NM_017934, a.a. 1146 - 1287 corresponding to bromodomain 1, with N-terminal His-tag, MW = 17 kDa, expressed in an E. coli cell expression system.
Background	PHIP is a bromodomain-containing protein that binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1 ), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival. It stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation.
Immunogen Region	1146 - 1287
Tag	N-terminal His-tag
Formulation	40 mM Tris-HCl, pH 8, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Species	Human
Application	Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Notes	Avoid freeze/thaw cycles.
GenBank	NM_017934
Mw(kda)	17 kDa

Synonyms	bromodomain pleckstrin homology domain interacting protein, IRS-1 PH Domain-Binding Protein, WDR11, BRWD2
Uniprot	Q8WWQ0

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	Store at -80°C. Stable for>6 months when stored as directed.

Reference	1. De Semir, D., et al., Proc. Natl. Acad. Sci. USA. 2012 May 1;109(18):7067-72. 2. Farhang-Fallah, J., et al., J. Biol. Chem. 2000 Dec 22;275(51):40492-7.

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200113	31140	100 ug	$335.50		Add to Cart

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