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Home / Proteins & Peptide

PDE7A, GST-tag

SKU : BHP18200522

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BPS Bioscience

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Mfr.No.	60070
Description	Human PDE7A1 GenBank Accession No. NM_002603), a.a. 121-end with N-terminal GST-tag, MW=66 kDa, expressed in a Baculovirus infected Sf9 cell expression system. host species: Sf9 cells Host species: Sf9 cells Specific activity: >= 180 pmol/min/ug Unit definition: One unit is defined as the amount of enzyme that will convert 1 pmole of 3', 5'-cAMP to 5'-AMP per minute at 37°C.
Immunogen Region	121-end
Tag	N-terminal GST-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 4 mM Glutathione, 0.04% Tween-20, 3 mM DTT, and 20% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Assayed using BPS's PDE7A kit, Cat. # 60370. Assay conditions: 10 mM Tris-HCl, pH 7.4, 10 mM MgCl₂, 0.1 mg/ml BSA, 0.05% Tween-20, 200 uM cAMP, 2.5 kU 5'-nucleotidase, and serial dilutions of PDE7A at 37°C for 20 min. Quantified by 5'- nucleotidase cleaving the 5' -AMP product and releasing the phosphate group which is detected by Malachite Green Reagent. Avoid freeze/thaw cycles.
GenBank	NM_002603
Mw(kda)	66 kDa

Synonyms	PDE7A, phosphodiesterase 7A
Uniprot	Q13946

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Wang, H., et al., J. Biol. Chem. 280(35):30949-30955 (2005). 2. Torras-Llort, M. and Azorin, F., Biochem. J. 373(PT 3):835-843 (2003).Application References: 1.Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance (2014) 2.PDE7A1 hydrolyzes cCMP (2014) The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey (2013)

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200522	60070	10 ug	$500.50		Add to Cart

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