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Home / Proteins & Peptide

PDE4D2, GST-tag

SKU : BHP18200512

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BPS Bioscience

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Mfr.No.	60048
Description	Human PDE4D2 (GenBank Accession No. NM_001197221), a.a. 2-507(end) with N-terminal GST tag, MW=84 kDa, expressed in a Baculovirus infected Sf9 cell expression system. host species: Sf9 cells Host species: Sf9 cells Specific activity: >= 13,600 pmol/min/ug Unit definition: One unit is defined as the amount of enzyme that will convert 1 pmole of 3', 5'-cAMP to 5'-AMP per minute at 37°C.
Immunogen Region	2-507(end)
Tag	N-terminal GST-tag
Formulation	40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20,20% glycerol, and 3 mM DTT.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	10 mM Tris-HCl,pH 7.4, 10 mM MgCl₂, 0.1 mg/ml BSA,0.05% Tween-20, 200 uM cAMP, 2.5 kU 5'-nucleotidase, andserial dilutions of PDE4D2 at 37°C for 20 min.Quantified by 5'- nucleotidase cleaving the5' -AMP product and releasing thephosphate group which is detected byMalachite Green Reagent. Avoid freeze/thaw cycles.
GenBank	NM_001197221
Mw(kda)	84 kDa

Synonyms	PDE4D2, phosphodiesterase 4D2
Uniprot	Q08499

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Fidani, L., et al., Eur. J. Neurol. 14 (7):745-749 (2007). 2. Baillie, G.S., et al., Biochem. J. 404 (1):71-80 (2007).Application Reference(s): 1.Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A (2015) 2.Evaluation of the therapeutic index of a novel phosphodiesterase 4B-selective inhibitor over phosphodiesterase 4D in mice (2013) 3.Synthesis of 2,2,4-trimethyl-1,2-dihydroquinolinyl substituted 1,2,3-triazole derivatives: their evaluation as potential PDE 4B inhibitors possessing cytotoxic properties against cancer cells (2014)

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200512	60048	5 ug	$572		Add to Cart

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