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PD-L1 (CD274), Fc fusion (Human) HiP

SKU : BHP18201535

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Mfr.No.	71104-2
Background	PD-L1 is involved in the costimulatory signal essential for T-cell proliferation and production of IL-10 and IFNgamma. Interaction with PD-1 inhibits T-cell proliferation and cytokine production, and down-regulates the immune response. PD
Immunogen Region	19-239
Tag	C-terminal Fc fusion (Human IgG1)
Description	Human secreted Programmed Cell Death 1 Ligand 1 (PD-L1)-Fc fusion protein, also known as CD274 and B7 homolog 1 (B7- H1), GenBank Accession No. NM_014143, amino acids 19-239, fused at the C-terminus to the Fc portion of human IgG1, expressed in a HEK293 cell expression system. MW = 52 kDa.
Formulation	8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Species	Human
Application	Useful for the study of protein-protein interaction and in vitro and in vivo protein function.
Notes	PD-L1 binding to PD-1 was tested following protocol for BPS Cat. #72005. Briefly, wells were coated with 10 ng of PD-L1 in PD-1 assay buffer. Varying concentrations of biotinylated PD-1 was added and wells were incubated at room temp. for 2 hours before adding strep-HRP, followed by chemiluminescent substrate. Luminescence was read on a chemiluminescent plate reader. This protein runs at a higher M.W. by SDS-PAGE due to glycosylation. The aggregation state of this product has been confirmed to be<10%. Avoid freeze/thaw cycles. Protein may be diluted to>=100 ug/ml in PBS + glycerol and stored at -80°C.
GenBank	NM_014143
Mw(kda)	52 kDa

Synonyms	Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1
Uniprot	Q9NZQ7

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Freeman, G.J., et al., J Exp Med. 2000 Oct 2;192(7):1027-34. 2. Dong, H., et al., Nat Med. 1999 Dec; 5(12):1365-9.Application Reference(s): Imai, Y., et al. J Immunol. 2015 Jul 15;195(2):421-5. doi: 10.4049/jimmunol.1500448. Cutting Edge: PD-1 Regulates Imiquimod-Induced Psoriasiform Dermatitis through Inhibition of IL-17A Expression by Innate gammadelta-Low T Cells (2015)

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18201535	71104-2	100 ug	$357.50		Add to Cart

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