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Home / Proteins & Peptide

NT-4, Human

SKU : BHP18500203

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iXCells Biotechnologies

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Mfr.No.	IX03000, IX03000-10, IX03000-50
Description	Neurotrophin-4 (NT-4), also known as NT-5, is a neurotrophic factor structurally related to beta-NGF, BDNF, and NT-3. Human NT-4 shares 48 - 52% aa sequence identity with human beta-NGF, BDNF, and NT-3.Neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds. NT-4 is expressed highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. NT-4 binds and induces receptor dimerization and activation of TrkB. NT-4 can signal through TrkB receptors and promotes the survival of peripheral sensory sympathetic neurons.Recombinant human Neurotrophin-4 (rhNT-4) produced in E.coli is a noncovalently linked homodimer containing two non-glycosylated polypeptide chains of 131 amino acids. A fully biologically active molecule, rhNT-4 has a molecular mass of 28.1kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Reconstitution	Reconstituted in 50mM acetic acid or ddH2O at 50 ug/ml.
Formulation	Lyophilized after extensive dialysis against 50mM acetic acid.
Molecular Weight	28.1 kDa, a noncovalently linked homodimer,of two 14.0 kDa polypeptide monomers.
Source	E. coli
Host	Human
Endotoxin Level	0.3 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 5.0 ug/ml, measured by a cell proliferation assay using C6 cells, corresponding to a specific activity of 2.0x 102 units/mg.

Synonyms	Neurotrophin-4, Neurotrophic 4/5 (NT-4/NT-5)
Sequence	MGVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVEVLGEVPAAGG SPLRQYFFET RCKADNAEEG GPGAGGGGCRGVDRRHWVSE CKAKQSYVRA LTADAQGRVG WRWIRIDTACVCTLLSRTGR A

Purity	95% by SDS-PAGE and HPLC analyses.
Storage	Lyophilized recombinant human Neurotrophin-4 (rhNT-4) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhNT-4 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500203-1	IX03000-10	10ug	$95		Add to Cart
BHP18500203-2	IX03000-50	50ug	$412		Add to Cart

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