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Home / Proteins & Peptide

NSD2 (catalytic domain), GST-tag

SKU : BHP18200420

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BPS Bioscience

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Mfr.No.	51026
Description	Human NSD2, also known as RE-IIBP, MMSET, and WHSC1 (GenBank Accession No. NM_133330), a.a. 941-1240 (catalytic domain) with N-terminal GST-tag, MW = 62 kDa, expressed in E. coli. Host cell line: E. coli Specific activity: 0.036 pmol/min/ug
Background	NSD2 is a histone methyltransferase that preferentially methylates Lys27 of histone H3. Isoform RE-IIBP may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. Mutations in the gene for NSD2 are linked to Wolf-Hirschhorn syndrome (WHS), a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4, and is also associated with chromosomal translocations in multiple myelomas.
Immunogen Region	941-1240
Tag	N-terminal GST-tag
Formulation	50 mM Tris-HCl, pH 8.5, 300 mM NaCl, 5 mM DTT, 10 mM glutathione, and 10% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Assay was performed using the BPS NSD2 Chemiluminescent Assay Kit (Cat. #53009) according to recommended protocol, with 5 uM S-adenosylmethionine on biotinylated H3 peptide-coated plates. Enzyme reaction was performed for 2 hours at room temperature. Avoid freeze/thaw cycles.
GenBank	NM_133330
Mw(kda)	62 kDa

Synonyms	WHSC1, Wolf-Hirschhorn Syndrome Candidate 1, MMSET, Multiple Myeloma SET Domain Containing Protein, NSD2, Nuclear SET Domain-Containing Protein 2, REIIBP, WHS, TRX5
Uniprot	O96028

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Kassambara A. et al., Biochem. Biophys. Res. Commun. 379 (4), 840-845 (2009). 2. Brito J.L. et al., Haematologica 94 (1), 78-86 (2009).

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200420	51026	50 ug	$495		Add to Cart

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