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Home / Proteins & Peptide

Noggin Fc Chimera, Mouse

SKU : BHP18500497

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iXCells Biotechnologies

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Mfr.No.	IX03379, IX03379-1, IX03379-50
Description	Noggin, also known as NOG, is a homodimeric glycoprotein that bindsto and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors. Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients, regulating cellular responses dependent on the local concentration of the signaling molecule.?Recombinant Mouse Noggin Fc Chimera produced in CHO cells is a polypeptide chain containing 446 amino acids with the C-termimal Mouse IgG1 Fc fragment. A fully biologically active molecule, rhNoggin has a molecular mass of 59 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized from a 0.2 um filtered solution in PBS.
Molecular Weight	59 kDa, observed by reducing SDS-PAGE.
Source	CHO
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Bioactivity	ED5020ng/ml, measured in a bioassay using ATDC5 cells in the presence of 10ng/ml Mouse BMP-4.

Synonyms	NOG
Sequence	LRAAPAGGQH YLHIRPAPSD NLPLVDLIEH PDPIFDPKEKDLNETLLRSL LGGHYDPGFM ATSPPEDRPG GGGGPAGGAEDLAELDQLLR QRPSGAMPSE IKGLEFSEGL AQGKKQRLSKKLRRKLQMWL WSQTFCPVLY AWNDLGSRFW PRYVKVGSCFSKRSCSVPEG MVCKPSKSVH LTVLRWRCQR RGGQRCGWIPIQYPIISECK CSCIEGRMDD KTHTCPPCPA PELLGGPSVFLFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDGVEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKCKVSNKALPAP IEKTISKAKG QPREPQVYTL PPSREEMTKNQVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSDGSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSLSLSPGK

Purity	97% as analyzed by reducing SDS-PAGE.
Storage	Lyophilized recombinant Mouse Noggin remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Mouse Noggin should be stable up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500497-1	IX03379-1	1mg	$1498		Add to Cart
BHP18500497-2	IX03379-50	50ug	$113		Add to Cart

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