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Noggin

SKU : BHP18201775

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BPS Bioscience

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Mfr.No.	90256-2
Description	Human Noggin, also known as symphalangism 1 (SYM1) or synostoses (multiple) syndrome 1 (SYNS1), GenBank Accession No. NM_005450, a.a. 28-232(end), disulfide-linked homodimer. MW=~28kDa (monomer). Source: human 293 cells. Endotoxin Level:<1 EU/ug. Biological Activity: measured by Noggin's ability to inhibit BMP-4-induced alkaline phosphatase production by C2C12 mouse myoblast cells. The ED50 is< 20 ng/ml in the presence of 30 ng/ml of human BMP-4. Formulation: Lyophilized from a 0.2 uM filtered, aqueous solution. Reconstitution: Supplied as a lyophilized solid. Reconstitute in sterile water with 0.1% BSA to a final concentration of 0.1 mg/ml. Final formulation will be 50 mM Tris, pH 8.0, 1.2 M NaCl, 2.7 mM KCl, 0.1% BSA.
Reconstitution	Reconstitute in sterile water with 0.1% BSA to a final concentration of 0.1 mg/ml. Final formulation will be 50 mM Tris, pH 8.0, 1.2 M NaCl, 2.7 mM KCl, 0.1% BSA. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid.
Background	Noggin is one of a group of proteins that act as secreted antagonists of BMP activity. BMPs are essential for osteogenesis and organogenesis during embryonic development, and also play a role in tissue healing in adults. Noggin inhibits BMP activity by binding to them with high affinity, blocking their ability to bind to their receptor.
Immunogen Region	28-232(end)
Tag	none
Formulation	Lyophilized from a 0.2 um filtered 0.1 mg/ml solution of 50 mM Tris, pH 8.0, 1.2 M NaCl, 2.7 mM KCl, 0.1% BSA
Species	Human
Application	Useful for cell culture and for the study of signaling and developmental pathways. Also useful for receptor binding studies, screening inhibitors, and selectivity profiling.
Endotoxin Level	< 1EU per ug of Noggin as determined by the LAL method.
Notes	Avoid freeze/thaw cycles.
Biological Activity Comment	Measured by Noggin's ability to inhibit BMP-4-induced alkaline phosphatase production by C2C12 mouse myoblast cells. The ED50 is<20 ng/ml in the presence of 30 ng/ml of human BMP-4.
GenBank	NM_005450
Mw(kda)	28 kDa

Synonyms	Noggin, symphalangism 1, SYM1, synostoses (multiple) syndrome 1, SYNS1
Uniprot	Q13253

Shipping Temperature	-80°C (dry ice)
Format	Lyophilized solid
Storage	>=12 months (lyophilized) at -20°C. Store reconstituted protein in aliquots at -20°C to -70°C for up to 6 months. Avoid freeze/thaw cycles.

Reference	1. Tao, Y.X., et al. (2010). Indian J. Exp. Biol. 48(5):444-52. 2. Mfopou, J.K., et al. (2010). Gastroenterology. 138(7):2233- 2245. 3. Chaturvedi, G., et al. (2009). Cell Prolif. 42(4):425-33

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SKU	Supplier No.	Size	Your price	Quantity
BHP18201775	90256-2	50 ug	$412.50		Add to Cart

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