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Home / Proteins & Peptide

Mouse JARID1B (KDM5B, PLU-1), FLAG-tag

SKU : BHP18200346

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BPS Bioscience

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Mfr.No.	50122
Description	Mouse JARID1B, also known as PLU-1 and KDM5B (GenBank Accession No. NM_152895), a.a. 2-751 with N-terminal FLAG-tag, MW = 86 kDa, expressed in Sf9 cells via a baculovirus expression system. Host cell line: Sf9 cells
Background	Histone demethylase that demethylates Lys-4 of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-9 or H3 Lys-27. Demethylates trimethylated, dimethylated and monomethylated H3 Lys-4. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
Immunogen Region	2-751
Tag	N-terminal FLAG-tag
Formulation	45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 90 g/ml FLAG peptide, 10% glycerol, and 3 mM DTT
Species	Mouse
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Avoid freeze/thaw cycles.
GenBank	NM_152895
Mw(kda)	86 kDa

Synonyms	JARID1B, PLU-1, KDM5B, Retinoblastoma-Binding Protein 2 Homolog 1, RBP2-H1, CT31, Cancer/Testis Antigen 31, PLU-1, Jumonji, AT Rich Interactive Domain 1B, Lysine-Specific Demethylase 5B
Uniprot	Q80Y84

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Yamane K, et al. (2007). Mol. Cell 25 (6): 801-12. 2. Barrett A, et al. (2007). Int. J.Cancer 121 (2): 265-75.Application Reference: An high-throughput in vivo screening system to select H3K4-specific histone demethylase inhibitors (2014)

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200346	50122	20 ug	$495		Add to Cart

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