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Home / Proteins & Peptide

MIP-1alpha/CCL3, Mouse

SKU : BHP18500411

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iXCells Biotechnologies

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Mfr.No.	IX03270, IX03270-25, IX03270-5
Description	MIP-1 alpha/CCL3, also known as LD78 alpha, is an inflammatory chemokine. MIP-1alpha belongs to the CCL chemokine family, and shares 68% homology with MIP-1beta. The mature form of MIP-1alpha contains 69 amino acids, exists as dimers in solution, and tends to undergo reversible aggregation. The receptors of MIP-1alphain vivo are mainly the G-protein coupled receptors CCR1 and CCR5. Upon stimulation by endogenous and exogenous agents such as Interleukin-1beta, Interferon-gamma, and lipoteichoic acid from gram-positive bacteria, monocytes are able to secrete significant amounts of MIP-1alpha. MIP-1alpha augments the adhesions of T lymphocytes, monocytes, and neutrophils to vascular cell adhesion molecule 1. Additionally, in wounds, MIP-1alphachemoattracts macrophages in order to accelerate the tissue repair process.Recombinant Mouse MIP-1 alpha/CCL3 (rmMIP-1alpha) produced in HEK 293cells is a single polypeptide chain containing 69 amino acids. A fully biologically active molecule, rmMIP-1alphahas a molecular mass of 7.8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	7.8 kDa, observed by reducing SDS-PAGE.
Source	HEK 293
Host	Mouse
Accession Number	Q5QNW0
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	The EC50 value of mouse MIP-1alpha/CCL3 on Ca2+ mobilization assay in CHO-K1/Galpha15/mCCR1 cells (human Galpha15 and mouse CCR1 stably expressed in CHO-K1 cells) is less than 100 ng/ml.

Synonyms	Macrophage Inflammatory Protein-1 alpha, CCL3, LD78 alpha
Sequence	APYGADTPTA CCFSYSRKIP RQFIVDYFET SSLCSQPGVIFLTKRNRQIC ADSKETWVQE YITDLELNA

Purity	95% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant Mouse MIP-1alpha/CCL3 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution Mouse MIP-1alpha/CCL3 should be stable up to 1 week at 4°C or up to 2 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500411-1	IX03270-25	25ug	$124		Add to Cart
BHP18500411-2	IX03270-5	5ug	$70		Add to Cart

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