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Home / Proteins & Peptide

MIP-1alpha/CCL3, Human

SKU : BHP18500293

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Mfr.No.	IX03131, IX03131-1, IX03131-10, IX03131-50
Description	MIP-1 alpha/CCL3, also known as LD78 alpha, is an inflammatory chemokine. MIP-1alpha belongs to the CCL chemokine family, and shares 68% homology with MIP-1beta. The mature form of MIP-1alpha contains 69 amino acids, exists as dimers in solution, and tends to undergo reversible aggregation. The receptors of MIP-1alphain vivo are mainly the G-protein coupled receptors CCR1 and CCR5. Upon stimulation by endogenous and exogenous agents such as Interleukin-1beta, Interferon-gamma, and lipoteichoic acid from Gram-positive bacteria, monocytes are able to secrete significant amounts of MIP-1alpha. MIP-1alpha augments the adhesions of T lymphocytes, monocytes, and neutrophils to vascular cell adhesion molecule 1. In addition, in wounds, MIP-1alpha chemo-attracts macrophages in order to accelerate the tissue repair process.Recombinant human MIP-1 alpha/CCL3 (rhMIP-1 alpha) produced in E. coli is a single non-glycosylated polypeptide chain containing 70 amino acids. A fully biologically active molecule, rhMIP-1 alpha has a molecular mass of 7.8 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	7.8 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Human
Accession Number	P10147
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 80 ng/mL, measured by the FLIPR assay using CHO cells transfected with human CCR5, the receptor of human CCL3, corresponding to a specific activity of 1.25x104 units/mg.

Synonyms	Macrophage Inflammatory Protein-1?, CCL3, LD78?
Sequence	ASLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGVIFLTKRSRQV CADPSEEWVQ KYVSDLELSA

Purity	95% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant human MIP-1 alpha/CCL3 (rhMIP-1 alpha) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhMIP-1 alpha remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500293-1	IX03131-1	1mg	$1498		Add to Cart
BHP18500293-2	IX03131-10	10ug	$82		Add to Cart
BHP18500293-3	IX03131-50	50ug	$199		Add to Cart

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