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Home / Proteins & Peptide

Metnase (SETMAR), FLAG-tag

SKU : BHP18200416

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Mfr.No.	51018
Description	Human Metnase (SETMAR, or SET domain and mariner transposase fusion), GenBank Accession No. NM_006515, a.a. 27-684(end), with N-terminal FLAG-tag, MW=76 kDa, expressed in FreeStyle 293-F cells. host species: human Host species: human Host cell line: Freestyle 293-F cells
Background	SETMAR or SET domain and mariner transposase fusion gene is a nonhomologous end-joining repair protein that regulates genomic integration of exogenous DNA by opening chromatin and facilitating joining of DNA ends. SETMAR has histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. SETMAR also has DNA nicking activity and may play a role in DNA repair. Human Pso4 forms a stable complex with SETMAR that regulates Metnase function in DNA repair. SETMAR has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element.
Immunogen Region	27-684(end)
Tag	N-terminal FLAG-tag
Formulation	45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 3 mM DTT, 90 g/ml FLAG peptide, and 10% glyceroll
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Avoid freeze/thaw cycles.
GenBank	NM_006515
Mw(kda)	76 kDa

Synonyms	Setmar, Metnase
Uniprot	Q53H47

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Wray J. et al., Blood 114(9), 1852-1858 (2009). 2. Williamson E.A. et al., Nucleic Acids Res. 36 (18), 5822-5831 (2008).

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200416	51018	20 ug	$484		Add to Cart

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