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Home / Proteins & Peptide

MEG-1 (PTPN4), GST-tag

SKU : BHP18200031

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Mfr.No.	30015
Description	MEG-1 protein tyrosine phosphatase (PTP-MEG-1), Genbank Accession No. NM_002830, a.a. 637-926 (catalytic domain) with N-terminal GST-tag, MW=60.3 kDa, expressed in an E. coli expression system. Specific activity: 4.6 U/ug Unit definition: One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C.
Background	PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP acts at junctions between the membrane and the cytoskeleton and has been shown to interact with glutamate receptor delta 2 and epsilon subunits. It also is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.
Immunogen Region	637-926
Tag	N-terminal GST-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 16 mM glutathione
Species	Human
Application	Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Notes	The specific activity was determined using pNPP. Assay conditions: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 20 mM pNPP, and 20 ng/ul enzyme for 5 minutes at 30°C. Avoid freeze/thaw cycles.
GenBank	NM_002830
Mw(kda)	60.3 kDa

Synonyms	MEG1, MEG-1, PTPN4, Megakaryocyte Phosphatase
Uniprot	P29074

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	>12 months at -80°C

Reference	1. K. Hironaka, et al., J. Biol.Chem. 2000, 275: 16167-16173 2. M. Gu, et al. Proc. Natl. Acad. Sci. 1996, 93: 12980-12985

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200031	30015	50 ug was 20 ug	$357.50		Add to Cart

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