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Home / Proteins & Peptide

MCP-2/CCL8, Human

SKU : BHP18500381

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iXCells Biotechnologies

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Mfr.No.	IX03232, IX03232-1, IX03232-25, IX03232-5
Description	MCP-2 is a member of the chemokines, a group of 70-80 residue proteins sharing substantial sequence similarity. Within the chemokines, MCP-2 belongs to the CC subfamily, and is a member of the Monocyte Chemoattractant Proteins (MCPs), which includes MCP-1, MCP-2, MCP-3, MCP-4, and MCP-5. MCP-2 shares 60% homology with MCP-1, and both proteins can undergo reversible dimerization. The main receptors of MCP-2 are G-protein coupled receptors CCR1 and CCR5. MCP-2 is a potential target in HIV-1 infected human glial cells as it may play a role in the modulation of viral spread in the brain. Recently, researchers found that mouse MCP-2 is expressed in the skin as a novel agonist of CCR8 and plays a role in eosinophilic inflammation.Recombinant human MCP-2/CCL8(rhMCP-2) produced in E. coli is a single non-glycosylated polypeptide chain containing 76 amino acids. A fully biologically active molecule, rhMCP-2 has a molecular mass of 8.9kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O at 100 ug/mL.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	8.9 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Human
Accession Number	P80075
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED500.5 ug/mL, measured by the FLIPR assay using CHO cells transfected with human CCR5, the receptor of human CCL8, corresponding to a specific activity of 2 x 103 units/mg.

Synonyms	Monocyte Chemoattractant Protein-2, HC14, SCYA8
Sequence	QPDSVSIPIT CCFNVINRKI PIQRLESYTR ITNIQCPKEAVIFKTKRGKE VCADPKERWV RDSMKHLDQI FQNLKP

Purity	95% by SDS-PAGE analysis.
Storage	Lyophilized recombinant human MCP-2/CCL8(rhMCP-2) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhMCP-2 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500381-1	IX03232-1	1mg	$1498		Add to Cart
BHP18500381-2	IX03232-25	25ug	$199		Add to Cart
BHP18500381-3	IX03232-5	5ug	$82		Add to Cart

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