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Home / Proteins & Peptide

LDLR, FLAG-Avi-Tag (Mouse)

SKU : BHP18200639

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Mfr.No.	71222
Description	Mouse low density lipoprotein receptor (LDLR), also known as FH, FHC, and LDLCQ2, GenBank Accession No. NM_010700, a.a. 22-790, with C-terminal Flag-tag, MW=87 kDa87, expressed in a HEK293 cell expression system. *Note: LDLR is heavily glycosylated, resulting in higher molecular weight.
Background	The low density lipoprotein receptor (LDLR protein) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. In case of HIV-1 infection, it functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR protein, inducing LDLR degradation.
Immunogen Region	22-790 (end)
Tag	C-terminal FLAG-Avi-tag
Formulation	40 mM Tris HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Species	Mouse
Application	Useful for studying protein binding and screening small molecules for drug discovery.
Notes	* LDLR is heavily glycosylated, resulting in higher molecular weight. The two bands shown correspond to differing states of glycosylation. Avoid freeze/thaw cycles.
GenBank	NM_010700
Mw(kda)	87 kDa

Synonyms	FH, FHC, LDLR, LDLCQ2, low density lipoprotein receptor
Uniprot	P35951

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C. Avoid freeze/ thaw cycles. Storing diluted protein is not recommended, if necessary, use a carrier protein (BSA 0.1 - 0.5%).

Reference	1. Holla, L., et al., BMC Cell Biol. 2007 Mar 1,8:9. 2. Qian, YW., et al., J Lipid Res. 2007 Jul,48(7):1488-98. 3. Fasano, T., et al., Athersclerosis. 2009 Mar,203(1):166-71.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200639	71222	50 ug	$500.50		Add to Cart

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