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Home / Proteins & Peptide

LAR (PTPRF), GST-tag

SKU : BHP18200041

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Mfr.No.	30046
Description	Human transmembrane leukocyte antigen related PTP (LAR), GenBank accession No. NM_130440, a.a. 1330-1620 (catalytic domain) with N-terminal GST-tag, MW=58 kDa, expressed in an E. coli expression system. Specific activity: 0.7 U/ug Unit definition: One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C.
Background	PTPRF or LAR is a member of the protein tyrosine phosphatase family with an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. PTPRF has been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance.
Immunogen Region	1330-1620
Tag	N-terminal GST-tag
Formulation	25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione
Species	Human
Application	Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Notes	20 mM HEPES, pH 7.2, 100 mM NaCl, 2 mM EDTA, 1 mM DTT, 1 mM pNPP and 160 ng/ul LAR. Assay was done at 30°C for 5 minutes, and the reaction was monitored at 405 nm continuously. Specific activity was calculated based on epsilon_pNPP= 18,000 M^-1cm^-1. Avoid freeze/thaw cycles.
GenBank	NM_130440
Mw(kda)	58 kDa

Synonyms	LAR, PTPRF, Leukocyte Antigen-Related PTP
Uniprot	P10586

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	>12 months at -80°C

Reference	1. H. Cho et al. Biochemistry 1991, 30: 6210-6216. 2. H. Cho et al. Biochemistry 1992, 31: 133-138.

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200041	30046	50 ug was 20 ug	$357.50		Add to Cart

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