Human secreted LAG3, also known as Lymphocyte-Activation Gene 3 and CD223. GenBank Accession No. NM 002286, a.a. 23-450 expressed in a HEK293 cell expression system with C-terminal His-Tag. MW = 48 kDa (monomer). This protein runs at a higher MW by SDS-PAGE due to glycosylation.
Immunogen Region
23-450
Tag
C-terminal His-Tag
Formulation
20 mM NaOAC, pH 5.5, 500 mM NaCl, 0.02% Tween 20 and 10% glycerol.
Species
Human
Application
Useful for studying protein binding and screening small molecular inhibitors
Notes
HiP indicates a high purity protein with>=90% purity as measured by gel filtration. Avoid freeze/thaw cycles.
GenBank
NM_002286
Mw(kda)
48 kDa
Synonyms
Lymphocyte-Activation Gene 3, CD223, Lag, Lag-3
Uniprot
P18627
Shipping Temperature
-80°C (dry ice)
Format
Aqueous buffer solution
Storage
At least 6 months at -80°C. Avoid freeze/thaw cycles. Protein may be diluted to>=100 ug/ml in PBS + glycerol and stored at -80°C.
Reference
1. Byrnes, et al. Cytometry A. 2012 Sep;81(2):165-8. 2. Di, Carlo., et al., J. Pathol. 2005 Jan; 205(1):82-91.